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Recombinant Mouse EphA2 Protein (His Tag)(Active)

SKU : BHP10305108

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040594
Description	A DNA sequence encoding the mouse EPHA2 (NP_034269.2) extracellular domain (Met 1-Asn 535) was expressed, fused with a polyhistidine tag at the C-terminus.
Alternative Names	AW545284;Eck;Myk2;Sek-2;Sek2
Reconstitution	Please refer to the printed manual for detailed information.
Background	Eph receptor A2 (Ephrin type-A receptor 2 or EphA2) is a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. The Eph receptors' corresponding family of ligands are the ephrins anchored to cell surfaces. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been found implicated in embryonic patterning, neuronal targeting, vascular development and adult neovascularization. The large family of ligands and receptors may make a major contribution to the accurate spatial patterning of connections and cell position in the nervous system. Furthermore, elevated expression of Eph receptors and ephrin ligands is associated with tumors and associated tumor vasculature, suggesting the Eph receptors and ephrin ligands also play critical roles in tumor angiogenesis and tumor growth. Unlike most Eph kinases, which are primarily expressed during development, EphA2 is primarily found in adult human epithelial cells. The cellular functions of EphA2 may be regulating cell growth, survival, migration, and angiogenesis.Unlike other receptor tyrosine kinases, ligand binding is not necessary for EphA2. Rather, the ligand appears to regulate EphA2 subcellular localization and its interactions with downstream adapter and signaling proteins. Eph receptor A2(EphA2) has been demonstrated to critically regulate tumor cell growth, migration and invasiveness. Eph receptor A2(EphA2) is frequently overexpressed and functionally altered in aggressive tumor cells, and that these changes promote metastatic character.
Reactivity	Mouse
Tag	C-His
Formulation	Lyophilized from sterile 20mM Tris, 150mM NaCl, pH 7.5
Host	HEK293 Cells
Accession Number	NP_034269.2
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	Measured by its binding ability in a functional ELISA.1. Immobilized mouse EphA2 at 2ug/ml (100 ul/well) can bind mouse EphrinA1 with a linear range of 0.16-20 ng/ml.2. Immobilized mouse EphA2 at 2 ug/ml (100 ul/well) can bind human EphrinA1 with a linear range of 0.8-20 ng/ml.
Mol Weight	58 kDa
Mw(kda)	58 kDa

Sequence Info	Met 1-Asn 535

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 98 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305108	PKSM040594	100ug	$805		Add to Cart

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