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Home / Proteins & Peptide

Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active)

SKU : BHP10305071

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040450
Description	A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Alternative Names	70Z-SHP;hcp;Hcph;me;Ptp1C;PTPTY-42;SH-PTP1;SHP-1
Reconstitution	Please refer to the printed manual for detailed information.
Background	PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
Reactivity	Mouse
Tag	N-His-GST
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerol
Host	Baculovirus-Insect Cells
Accession Number	P29351-2
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method.
Bioactivity	Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 4 umoles/min/ug.
Mol Weight	72.7 kDa
Mw(kda)	72.7 kDa

Sequence Info	Ala207-Lys597

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 85 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305071	PKSM040450	100ug	$855		Add to Cart

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