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Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1(Ripk1)

SKU : BHP10504973

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP720181MO
Alternative Names	Cell death protein RIPReceptor-interacting protein 1, Cell death protein RIP Receptor-interacting protein 1
Antigen	Ripk1
Tag	N-terminal 6xHis-sumostar-tagged
Description	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. Interacts with ARHGEF2
Regulatory	RUO
Relevance	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex. Interacts with ARHGEF2
Source	Yeast
Abbreviation	Ripk1
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Receptor-interacting serine/threonine-protein kinase 1 EC= 2.7.11.1Alternative name(s): Cell death protein RIP Receptor-interacting protein 1 Short name= RIP-1 Serine/threonine-protein kinase RIP
Expression Region	1-656aa
Mol Weight	88kDa
Nature	Recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Cell membrane
Uniprot	Q60855, Q60855
Database Links	KEGG:mmu:19766 STRING:10090.ENSMUSP00000021844 UniGene:Mm.374799
Function	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity).
Pathway	NF-kappa B signaling pathway; TNF signaling pathway; Apoptosis; Necroptosis; NOD-like receptor signaling pathway; Toll-like receptor signaling pathway
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family
Research Area	Cell Biology
Tissue Specificity	Found at low levels in all tissues.
Weight	90.9 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504973	CSB-YP720181MO	500ug	$1298		Add to Cart
BHP10504973	CSB-YP720181MO	100ug	$470		Add to Cart
BHP10504973	CSB-YP720181MO	20ug	$250		Add to Cart

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