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Home / Proteins & Peptide

Recombinant Rat ALK4/ACVR1B Protein (Fc Tag)(Active)

SKU : BHP10305770

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030351
Description	A DNA sequence encoding the rat ACVR1B (Met1-Glu126) was expressed with the Fc region of human IgG1 at the C-terminus.
Alternative Names	ACVR1B;Acvrlk4;Alk4
Reconstitution	Please refer to the printed manual for detailed information.
Background	ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
Reactivity	Rat
Tag	C-Fc
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_954700.1
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	Measured by its ability to bind with rat TDGF1-His in a functional ELISA.
Mol Weight	38.4 kDa
Mw(kda)	38.4 kDa

Sequence Info	Met1-Glu126

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305770	PKSR030351	100ug	$732		Add to Cart

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