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Home / Proteins & Peptide

Recombinant Rat PCSK9 Protein (His Tag)(Active)

SKU : BHP10305820

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030410
Description	A DNA sequence encoding the rat PCSK9 (NP_954862.2) (Met 1-Gln 691) was expressed, fused with a polyhistidine tag at the C-terminus.
Alternative Names	NARC-1;Narc1;PC9;Pcsk9
Reconstitution	Please refer to the printed manual for detailed information.
Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons. References
Reactivity	Rat
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_954862.2
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	1. Measured by its ability to bind biotinylated human LDLR in a functional ELISA.2. Measured by its ability to bind biotinylated mouse LDLR in a functional ELISA.
Mol Weight	72.8 kDa
Mw(kda)	72.8 kDa

Sequence Info	Met 1-Gln 691

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305820	PKSR030410	20ug	$454		Add to Cart

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