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Home / Proteins & Peptide

Recombinant Rat TNFSF7/CD70 Protein (His Tag)(Active)

SKU : BHP10305836

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSR030431
Description	A DNA sequence encoding the rat CD70 (NP_001100348) (Gln46-Pro195) was expressed, fused with a polyhistidine tag at the N-terminus.
Alternative Names	CD70
Reconstitution	Please refer to the printed manual for detailed information.
Background	CD70, a member of the tumor necrosis factor superfamily, is restricted to activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor, CD27, is important in priming, effector functions, differentiation and memory formation of T-cells as well as plasma and memory B-cell generation. Tight control of CD70 expression is required to prevent lethal immunodeficiency. By selective transcription, CD70 is largely confined to activated lymphocytes and dendritic cells (DC). As a type II transmembrane receptor, CD70 is normally expressed on a subset of B, T and NK cells, where it plays a costimulatory role in immune cell activation. Immunohistochemical analysis of CD70 expression in multiple carcinoma types. The restricted expression pattern of CD70 in normal tissues and its widespread expression in various malignancies makes it an attractive target for antibody-based therapeutics. Investigations to exploit CD70 as a cancer target have lead to the identification of potential antibody-based clinical candidates.Immune CheckpointImmune Checkpoint ProteinsImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Reactivity	Rat
Tag	N-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_001100348
Endotoxin Level	< 1.0 EU per ?g of the protein as determined by the LAL method
Bioactivity	1.Measured by its binding ability in a functional ELISA.2.Immobilized rat His-CD70 at 10ug/mL (100uL/well) can bind mouse CD27-Fch , the EC50 of mouse CD27-Fch is 10-50ng/mL.
Mol Weight	18.9 kDa
Mw(kda)	18.9 kDa

Sequence Info	Gln46-Pro195

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by SDS-PAGE

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305836	PKSR030431	50ug	$389		Add to Cart

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