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Home / Proteins & Peptide

Recombinant SARS-CoV-2 Spike S1(D614G)(His Tag)(Active)

SKU : BHP10306387

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSV030387
Reconstitution	Not Applicable
Background	The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
Tag	C-10His
Formulation	Supplied as a 0.2 uM filtered solution of PBS, pH 7.4.
Species	SARS-CoV-2
Host	Human Cells
Accession Number	QHD43416.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Accurate Molecular Mass(kd)	76.6kDa
Predicted Molecular Mass(kd)	100-130kDa
Protein Description	Recombinant 2019-nCoV S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685(D614G) is expressed with a 10His tag at the C-terminus.

Synonyms	S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
Research Area	Virus related Protein
Sequence	Gln14-Arg685(D614G)

Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Purity	> 95 % as determined by reducing SDS-PAGE.
Storage	Store at< -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Immunological Activity	Immobilized Recombinant Human ACE-2 Protein (Fc Tag)(Active)(Cat#PKSR030492) at 5ug/ml (100 ul/well) can bind Recombinant 2019-nCoV S1 Protein (His Tag)(D614G)(Active)(Cat#PKSV030387).The ED50 of PKSV030387 is 1.43 ug/ml.

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SKU	Supplier No.	Size	Your price	Quantity
BHP10306387	PKSV030387	50ug	$290		Add to Cart
BHP10306387	PKSV030387	500ug	-		Add to Cart

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