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Home / Proteins & Peptide

Recombinant Human Hepatitis B virus X-interacting protein(HBXIP)

SKU : BHP10503688

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP010161HU
Alternative Names	Hepatitis B virus X-interacting protein
Antigen	LAMTOR5
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Hepatitis B virus X-interacting protein; Short name= HBV X-interacting protein; Short name= HBX-interacting protein
Expression Region	1-91aa
Mol Weight	36.6kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Lysosome
Uniprot	O43504, O43504
Database Links	HGNC:17955 OMIM:608521 KEGG:hsa:10542 STRING:9606.ENSP00000256644 UniGene:Hs.439815
Function	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.
Pathway	mTOR signaling pathway
Protein Families	LAMTOR5 family
Research Area	Cell Biology
Tissue Specificity	Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HB
Weight	37.501kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503688	CSB-EP010161HU	1mg	$1812		Add to Cart
BHP10503688	CSB-EP010161HU	100ug	$419		Add to Cart
BHP10503688	CSB-EP010161HU	20ug	$224		Add to Cart

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