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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (PLCD4)

SKU : BHP10501540

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP866264HU
Alternative Names	Phosphoinositide phospholipase C-delta-4Phospholipase C-delta-4 ,PLC-delta-4, Phosphoinositide phospholipase C-delta-4Phospholipase C-delta-4 ; PLC-delta-4
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca2+ mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-762aa
Mol Weight	103.6kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Membrane, Peripheral membrane protein, Nucleus, Cytoplasm, Endoplasmic reticulum
Uniprot	Q9BRC7, Q9BRC7
Database Links	HGNC:9062 OMIM:605939 KEGG:hsa:84812 STRING:9606.ENSP00000388631 UniGene:Hs.632528
Function	Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation.
Pathway	Calcium signaling pathway; AGE-RAGE signaling pathway in diabetic complications; Phosphatidylinositol signaling system
Research Area	Signal Transduction
Tissue Specificity	Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells.
Weight	103.53kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501540	CSB-EP866264HU	20ug	$224		Add to Cart
BHP10501540	CSB-EP866264HU	100ug	$419		Add to Cart
BHP10501540	CSB-EP866264HU	1mg	$1812		Add to Cart

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