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Home / Proteins & Peptide / Recombinant Protein

Recombinant Human Corticotropin-releasing factor receptor 1 (CRHR1), partial

SKU : BHP10500445

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP005965HU
Alternative Names	Corticotropin-releasing hormone receptor 1 ,CRH-R-1 ,CRH-R1, Corticotropin-releasing hormone receptor 1 ; CRH-R-1 ; CRH-R1
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal bryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	24-121aa
Mol Weight	37.9kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Cell membrane, Multi-pass membrane protein, Endosome
Uniprot	P34998, P34998
Database Links	HGNC:2357 OMIM:122561 KEGG:hsa:104909134 STRING:9606.ENSP00000381333 UniGene:Hs.417628
Function	G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
Protein Families	G-protein coupled receptor 2 family
Research Area	Neuroscience
Tissue Specificity	Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
Weight	38.3kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500445	CSB-EP005965HU	20ug	$224		Add to Cart
BHP10500445	CSB-EP005965HU	100ug	$419		Add to Cart
BHP10500445	CSB-EP005965HU	1mg	$1812		Add to Cart

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