Recombinant Human Density-regulated protein (DENR)

Mfr.No.	CSB-EP006724HU
Alternative Names	Protein DRP1Smooth muscle cell-associated protein 3 ,SMAP-3, Protein DRP1Smooth muscle cell-associated protein 3 ; SMAP-3
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	2-198aa
Mol Weight	38.0kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Uniprot	O43583, O43583
Database Links	HGNC:2769 OMIM:604550 KEGG:hsa:8562 STRING:9606.ENSP00000280557 UniGene:Hs.22393
Function	May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.
Protein Families	DENR family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.
Weight	37.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol