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Home / Biochemicals / Small Molecules

(-)-Cytisine

SKU : BHB21300074

A nAChR Agonist and a Partial Agonist of beta2 Subunit

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Mfr.No.	C-130, C-130_10 mg, C-130_100 mg, C-130_25 mg, C-130_250 mg, C-130_50 mg
Description	(-)-Cytisine (#C-130) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H14N2O.
Synonyms	Synthetic
Background	(-)-Cytisine is an alkaloid, which occurs naturally in several types of plants as well as in animals feeding on them (see example in reference 1). (-)-Cytisine is a potent and selective agonist of neuronal nAChR2. It acts as a partial agonist of beta2-containing nAChR3.EC50s differ for different subunit-composed channels; for recombinant human channels expressed in Xenopus oocytes the following EC50 values were reported: 25 uM, 39 uM, 67 uM, 72 uM, 2.6 uM 0.9 uM and 71 uM for alpha2/beta2, alpha2/beta4, alpha3/beta2, alpha3/beta4, alpha4/beta2, alpha4/beta4 and alpha7 respectively4.However, in beta2-containing channels, the response to acetylcholine (ACh) is largely reduced when applied in combination with (-)-Cytisine5. Therefore, when applied in vivo it exerts a compound effect of both activating certain nAchRs and inhibiting the effect of ACh on others. For example, (-)-Cytisine was found to have antidepressant-like effects in several animal models of antidepressant efficacy. This was probably achieved by inhibiting the effect of ACh on alpha2/beta4 channel in the basolateral amygdala6.In another study, the effects of (-)-Cytisine were compared to nicotine. Rats were trained to discriminate nicotine from saline and it was confirmed that (-)-Cytisine had a nicotine-like discriminative effect, but it was much less potent than nicotine itself7.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	40 nM - 1 uM.
Reconstitution	Any aqueous buffer (up to 100mM stock). Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	485-35-8
Molecular Weight	190.2
Solubility	Any aqueous buffer (up to 100mM stock). Centrifuge all product preparations before use (10000 x g 5 min).
Target	nAChR
Activity	(-)-Cytisine is a potent and selective agonist of neuronal nAChR. It acts as a partial agonist at beta2-containing nAChR1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido(1,2-a)(1,5)diazocin-8-one.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to one week at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Banko, P.C. et al. (2002) J. Chem. Ecol. 28, 1393. Albuquerque, E.X. et al. (2009) Physiol. Rev. 89, 73. Luetje, C.W. and Patrick, J. (1991) J. Neurosci. 11, 837. Chavez-Noriega, L.E. et al. (1997) J. Pharmacol. Exp. Ther. 280, 346. Papke, R.L. and Heinemann, S.F. (1994) Mol. Pharmacol. 45, 142. Mineur, Y.S. et al. (2007) Neuropharmacology 52, 1256. Reavill, C. et al. (1990) Neuropharmacology 29, 619. Albuquerque, E.X. et al. (2009) Physiol. Rev. 89, 73. Luetje, C.W. and Patrick, J. (1991) J. Neurosci. 11, 837.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300074-1	C-130_10 mg	10 mg	$55		Add to Cart
BHB21300074-2	C-130_100 mg	100 mg	$354		Add to Cart
BHB21300074-3	C-130_25 mg	25 mg	$111		Add to Cart
BHB21300074-4	C-130_250 mg	250 mg	$805		Add to Cart
BHB21300074-5	C-130_50 mg	50 mg	$188		Add to Cart

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