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Home / Biochemicals / Small Molecules

(S)(-)-Bay K8644

SKU : BHB21300066

An Activator of L-Type CaV Channels

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Mfr.No.	B-351, B-351_1 mg, B-351_10 mg, B-351_100 mg, B-351_25 mg, B-351_5 mg, B-351_50 mg
Description	(S)(-)-Bay K8644 (#B-351) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H15 F3N2O4.
Background	(S)(-)-Bay K8644 is an L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is an enantiomer of (±)-Bay K8644. (S)(-)-Bay K8644 is a dihydropyridine that can, among other effects, constrict blood vessels and increase the force of contraction of the heart. The drug is thought to increase the entry of Ca2+ into cells by increasing the open-state probability of Ca2+ channels, either by prolonging the duration of individual openings or by increasing the number of openings. It was noted in early experiments with Bay K8644 that the dose-response curve is biphasic1. The action of (S)(-)-Bay K8644 was studied in rat tail artery and guinea pig ileal longitudinal smooth muscle using pharmacologic and radioligand binding assays. It induced concentration-dependent contractions in both smooth muscle preparations with EC50 values of 1.98-11 nM. With increasing concentrations, (S)(-)-Bay K8644 relaxed the tissue with IC50 values of 0.53-2.60 uM2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 5 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
Cas Number	98625-26-4
Molecular Weight	356.3
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	L-type Ca2+ channels
Source	Synthetic
Activity	(S)(-)-Bay K8644 is an L-type Ca2+-channel activator. It displays vasoconstrictive effects in vivo1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (4S)-1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylic acid methyl ester.

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hadley, R.W. and Hume, J.R. (1988) Circ. Res. 62, 97. Wei, X.Y. et al. (1986) J. Pharmacol. Exp. Ther. 239, 144. Franckowiak, G. et al. (1985) Eur. J. Pharmacol. 114, 223.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300066-1	B-351_1 mg	1 mg	$92		Add to Cart
BHB21300066-2	B-351_10 mg	10 mg	$266		Add to Cart
BHB21300066-3	B-351_100 mg	100 mg	$1344		Add to Cart
BHB21300066-4	B-351_25 mg	25 mg	$531		Add to Cart
BHB21300066-5	B-351_5 mg	5 mg	$192		Add to Cart
BHB21300066-6	B-351_50 mg	50 mg	$845		Add to Cart

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