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Home / Biochemicals / Small Molecules

17-AAG

SKU : BHB21300048

An Anticancer Antibiotic

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Alomone Labs

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Mfr.No.	A-580, A-580_0.1 mg
Description	17-AAG (#A-580) is a highly pure, semi-synthetic, and biologically active compound.
Molecular Formula	C31H43N3O8.
Synonyms	Semi-synthetic
Background	17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function.1 Hsp90 regulates the physiology of cells exposed to environmental stress and in maintaining the malignant phenotype of tumor cells. 17-AAG induces apoptosis and displays anti-tumor effects in tumor cells. 17-AAG depletes cancer cells of erbB-1, erbB-2, Raf-1, and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways.2,3 It also downregulates vascular endothelial growth factor (VEGF) expression.4 17AAG is currently in phase I clinical trial in several centers worldwide.5-8 Preliminary data obtained from these trials demonstrate that anti-tumor activity is achieved at concentrations below the maximum tolerated dose.9
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50-100 nM.
Reconstitution	DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	75747-14-7
Molecular Weight	585.7
Solubility	DMSO, methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	17-AAG is a less toxic and more stable derivative of the antibiotic Geldanamycin. It binds to Hsp90 and regulates its function and displays anti-tumor effects1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 17-Demethoxy-17-(2-propenylamino) geldanamycin.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Clarke, P.A. et al. (2000) Oncogene 19, 4125. Basso, A.D. et al. (2002) Oncogene 21, 1159. Schnur, R.C. et al. (1995) J. Med. Chem. 38, 3806. Nguyen, D.M. et al. (2001) Ann. Thorac. Surg. 72, 371. Yang, J. et al. (2001) Cancer Res. 61, 4010. Nimmanapalli, R. et al. (2001) Cancer Res. 61, 1799. Neckers, L. (2002) Clin Cancer Res. 8, 962. Bagatell, R. et al. (2001) Clin. Cancer Res. 7, 2076. Chiosis, G. et al. (2003) Mol. Cancer Ther. 2, 123. Clarke, P.A. et al. (2000) Oncogene 19, 4125. Basso, A.D. et al. (2002) Oncogene 21, 1159. Schnur, R.C. et al. (1995) J. Med. Chem. 38, 3806.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300048-1	A-580_0.1 mg	0.1 mg	$188		Add to Cart
BHB21300048-2	A-580_0.1 mg	5x0.1 mg	$737		Add to Cart

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