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Home / Biochemicals / Small Molecules

4,9-Anhydrotetrodotoxin

SKU : BHB21300355

A Potent and Selective Blocker of NaV1.6 Channel

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Mfr.No.	T-560, T-560_5 mcg
Description	4,9-Anhydrotetrodotoxin (#T-560) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H15N3O7.
Synonyms	Synthetic
Background	4,9-Anhydrotetrodotoxin, also called 4,9-anhydro-TTX, is a derivative of tetrodotoxin, a potent neurotoxin found in a number of marine creatures including the pufferfish. 4,9-Anhydro-TTX acts as a potent and selective NaV1.6 channel blocker with an IC50 value of 7.8 nM1.4,9-Anhydrotetrodotoxin was found to block the activity of NaV1.6 channels with an efficacy of 40-160 times higher than other tetrodotoxin sensitive NaV1.x channel isoforms. The compound successfully prevents the influx of Na+ ions by blocking the pore of the NaV channel from the extracellular side of the plasma membrane2.4,9-Anhydrotetrodotoxin has become a useful pharmacological tool for the investigation and identification of the biophysical properties of NaV1.6 channels2.Voltage-gated sodium (NaV) channels are responsible for initiating action potentials in electrically excitable cells. NaV channels play an important role in human pain signaling pathways and are an important therapeutic target for the treatment of chronic pain. Mutations in NaV channels are also associated with a range of complex pathologic conditions such as epilepsy, myotonic conditions and cardiac arrhythmias3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 nM.
Reconstitution	Ethanol, Methanol up to 10 mM. Less soluble directly in aqueous solution.
Cas Number	13072-89-4
Molecular Weight	301.25
Solubility	Ethanol, Methanol up to 10 mM. Less soluble directly in aqueous solution.
Target	NaV1.6 channel
Activity	4,9-Anhydrotetrodotoxin, a derivative of tetrodotoxin, is a potent blocker of the NaV1.6 channel (IC50 = 7.8 nM), selective over other TTX-sensitive sodium channels1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)- 6,10-epoxy-4,8,11a-metheno-11aH-oxocino(4,3-f)(1,3,5)oxadiazepine-6,9,11-triol.

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage of solutions: Unstable. Avoid storing in aqueous solution. Prepare fresh daily and use immediately. Toxic.

Product Manual	SDS

Reference	Rosker, C. et al. (2007) Am. J. Physiol. 293, C783. Teramoto, N. and Yotsu-Yamashita, M. (2015) Mar. Drugs. 13, 984. Cardoso, F.C. et al. (2015) Mol. Pharmacol. 88, 291. Namadurai, S. et al. (2015) Open Biol. 5, 140192. Rosker, C. et al. (2007) Am. J. Physiol. 293, C783.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300355-1	T-560_5 mcg	5 mcg	$1003		Add to Cart

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