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Home / Biochemicals / Small Molecules

5,7-Dichlorokynurenic acid monohydrate

SKU : BHB21300121

An Antagonist of NMDA Receptors

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Mfr.No.	D-191, D-191_10 mg, D-191_100 mg, D-191_25 mg, D-191_250 mg, D-191_50 mg
Description	5,7-Dichlorokynurenic acid monohydrate (#D-191) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H7Cl2NO4.
Background	5,7-Dichlorokynurenic acid (5,7-DCKA), is a derivative of kynurenic acid, an extremely potent excitatory amino acid receptor antagonist of N-methyl-D-aspartate (NMDA) receptors. 5,7-DCKA binds with high affinity to a strychnine-insensitive glycine binding site located on the NMDA receptor. This site is considered to be used as a therapeutic target for acute focal ischemia. The compound exhibits strong selectivity for binding to GluN1 subunit over GluN3A1,2 with an IC50 value of 79 nM in rat cortical and hippocampal membranes4.Small concentrations of 5,7-DCKA have the ability to inhibit several processes including NMDA-stimulated elevation of cytosolic calcium in cultured hippocampal neurons, cGMP accumulation in cerebellar slices, and norepinephrine release from hippocampal regions1.Several different studies have demonstrated potent anticonvulsant features of 5,7-DCKA when the compound is administrated intra-cerebroventricularly directly to the brain1.NMDA receptors play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. They mediate several physiological functions including learning and memory formation; they play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-20 uM.
Reconstitution	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	190908-40-8
Molecular Weight	276.07
Solubility	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	NMDA receptors
Source	Synthetic
Activity	5,7-Dichlorokynurenic acid is an NMDA receptor antagonist acting at the glycine site1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5,7-dichloro-4-oxo-1H-quinoline-2-carboxylic acid; hydrate.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Baron, B.M. et al. (1990) Mol. Pharmacol. 38, 554. Kvist, T . et al. (2013) Neuropharmacology 75, 324. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45. Baron, B.M. et al. (1991) Eur. J. Pharmacol. 206, 149. Baron, B.M. et al. (1990) Mol. Pharmacol. 38, 554.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300121-1	D-191_10 mg	10 mg	$117		Add to Cart
BHB21300121-2	D-191_100 mg	100 mg	$843		Add to Cart
BHB21300121-3	D-191_25 mg	25 mg	$263		Add to Cart
BHB21300121-4	D-191_250 mg	250 mg	$1426		Add to Cart
BHB21300121-5	D-191_50 mg	50 mg	$468		Add to Cart

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