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Home / Biochemicals / Small Molecules

5'-Iodoresiniferatoxin

SKU : BHB21300182

A Potent and Partial Blocker of TRPV1 Channel

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Mfr.No.	I-800, I-800_0.1 mg, I-800_0.5 mg, I-800_1 mg
Description	5 -Iodoresiniferatoxin (#I-800) is a highly pure, semi-synthetic, and biologically active compound.
Molecular Formula	C37H39IO9.
Synonyms	Semi-synthetic
Background	5'-Iodoresiniferatoxin (5'-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5'-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC50 = 3.9 nM).1 5'-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on CaV currents (probably mediated by TRPV1) in DRG neurons.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 10 uM.
Reconstitution	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	535974-91-5
Molecular Weight	754.6
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels
Activity	5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1. It also abolishes the inhibitory effect of capsaicin on CaV currents in DRG neurons2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.Protect from light.

Product Manual	SDS

Reference	Wahl, P. et al. (2001) Mol. Pharmacol. 59, 9. Wu, Z.Z. et al. (2005) J. Biol. Chem. 280, 18142. Wahl, P. et al. (2001) Mol. Pharmacol. 59, 9. Wu, Z.Z. et al. (2005) J. Biol. Chem. 280, 18142.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300182-1	I-800_0.1 mg	0.1 mg	$579		Add to Cart
BHB21300182-2	I-800_0.5 mg	0.5 mg	$2313		Add to Cart
BHB21300182-3	I-800_1 mg	1 mg	$3699		Add to Cart

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