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Home / Biochemicals / Small Molecules

A-889425

SKU : BHB21300006

A Blocker of TRPV1 Channels

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Alomone Labs

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Mfr.No.	A-195, A-195_1 mg, A-195_10 mg, A-195_25 mg, A-195_5 mg, A-195_50 mg
Description	A-889425 (#A-195) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H18F3N3O3S.
Background	TRPV1 (transient receptor potential vanilloid family type 1) channels are activated and/or modulated by noxious heat, capsaicin, protons and other endogenous agents released following tissue injury.A-889425 is a selective and competitive TRPV1 channel blocker with an IC50 of 335 nM to displace capsaicin at rat receptors, and has good penetration into the CNS1. In the somatic sensory system, receptor-selective TRPV1 antagonists, such as A-889425, attenuate mechanical hyperalgesia in models of inflammatory, osteoarthritic, and neuropathic pain2. Administration of A-889425 inhibited mechanically evoked activity of wide dynamic range (WDR) neurons in the rat spinal dorsal horn under conditions of peripheral inflammation but not in uninjured rats1.In addition to actions on the nociceptive system, several TRPV1 blockers like A-889425 have been reported to affect thermoregulation by transiently raising core body temperature following systemic administration in both animals and humans3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5 nM - 50 uM.
Reconstitution	DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	1072921-02-8
Molecular Weight	425.4
Solubility	DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	TRPV1 channels
Source	Synthetic
Activity	A-889425 blocks TRPV1 channels with an IC50 of 335 nM (rat) and 34 nM (human)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(3-methylpyridin-2-yl)-N-(4-(trifluoromethylsulfonyl)phenyl)-1,2,3,6-tetrahydropyridine-4-carboxamide.

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Chu K.L. et al. (2011) Brain Res. 1369, 15. Gavva, N.R. et al. (2008) Pain 136, 202. McGaraughty, S. et al. (2008) J. Neurophysiol. 100, 3158. McGaraughty, S. et al. (2008) J. Neurophysiol. 100, 3158.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300006-1	A-195_1 mg	1 mg	$117		Add to Cart
BHB21300006-2	A-195_10 mg	10 mg	$354		Add to Cart
BHB21300006-3	A-195_25 mg	25 mg	$805		Add to Cart
BHB21300006-4	A-195_5 mg	5 mg	$261		Add to Cart
BHB21300006-5	A-195_50 mg	50 mg	$1474		Add to Cart

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