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Home / Biochemicals / Small Molecules

A 967079

SKU : BHB21300009

A Blocker of TRPA1 Channels

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Alomone Labs

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Mfr.No.	A-225, A-225_10 mg, A-225_100 mg, A-225_25 mg, A-225_250 mg, A-225_5 mg, A-225_50 mg
Description	A 967079 (#A-225) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C12H14FNO.
Background	The transient receptor potential (TRP) channel is one of the largest families of cation channels1.TRPA1 is expressed in sensory and nociceptive neurons and has a significant role in the inflammatory response. Bradykinin and histamine receptors induce TRPA1 activity. It has been found that TRPA1 deficient mice do not develop an elevated mechanical and thermal pain response following bradykinin injection. This suggests that TRPA1 has a vital role in bradykinin signaling pathways2.TRPA1 also plays a role in acute and chronic respiratory disease pathophysiology. Prolonged exposure to TRPA1 agonists such as chlorine and aldehydes can cause reactive airway dysfunction syndrome characterized by symptoms such as wheezing, cough and dyspnea. In view of this, TRPA1 is a potential target in airway anti-inflammatory research3.A 967079 is a TRPA1 blocker and has an IC50 value of 67 and 289 nM for human and rat TRPA1 receptors respectively.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 100 uM.
Reconstitution	Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Cas Number	1170613-55-4
Molecular Weight	207.2
Solubility	Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	TRPA1 channels
Source	Synthetic
Activity	A 967079 is a blocker of TRPA1 channels and has IC50 values of 67 and 289 nM at human and rat TRPA1 receptors respectively1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (NZ)-N-((E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-ylidene)hydroxylamine.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Levine, J.D. and Alessandri-Haber, N. (2007) Biochim. Biophys. Act. 1772, 989. Bautista, D.M. (2006) Cell 124, 1269. Bessac, B.F. and Jordt, S. (2008) Physiology 23, 360. McGaraughty, S. et al. (2010) Mol. Pain 6, 14.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300009-1	A-225_10 mg	10 mg	$92		Add to Cart
BHB21300009-2	A-225_100 mg	100 mg	$460		Add to Cart
BHB21300009-3	A-225_25 mg	25 mg	$151		Add to Cart
BHB21300009-4	A-225_250 mg	250 mg	$916		Add to Cart
BHB21300009-5	A-225_5 mg	5 mg	$76		Add to Cart
BHB21300009-6	A-225_50 mg	50 mg	$266		Add to Cart

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