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Home / Biochemicals / Small Molecules

AF-353

SKU : BHB21300029

A Potent and Selective Antagonist of P2X3 Receptor

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Mfr.No.	A-375, A-375_10 mg, A-375_25 mg, A-375_5 mg, A-375_50 mg
Description	AF-353 (#A-375) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C14H17IN4O2.
Synonyms	Synthetic
Background	AF-353 is a highly potent and selective antagonist of P2X3 and P2X2/3 purinergic receptors. The compound is orally bioavailable and is being used as an in vivo tool for studying the role of P2X channels in animal pain models.P2X receptors are a family of ion channels that are gated by ATP. They are expressed in cell types of almost every origin, including neuronal, muscular, epithelial and immune and have been shown to play a pivotal role in models of various pain conditions1.Antagonism of P2X3 receptors can reduce arterial pressure and basal sympathetic activity and normalizes carotid body hyper-reflexia in rats with hypertension2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 10 uM.
Reconstitution	Up to 25mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	865305-30-2
Molecular Weight	400.21
Solubility	Up to 25mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	P2X3 receptors
Activity	AF-353 is a highly potent and selective P2X3 and P2X2/3 receptor antagonist. pIC50 for these receptors, measured using intracellular calcium assays and whole-cell voltage-clamp, range from 7.4 to 8.51.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine.

Purity	>95% (HPLC)
Form	Lyophilized powder.
Storage	Storage of solutions: -20°C.

Product Manual	SDS

Reference	Gever, J.R. et al. (2010) Br. J. Pharmacol. 160, 1387. Pijacka, W. et al. (2016) Nat. Med. 22, 1151. Gever, J.R. et al. (2010) Br. J. Pharmacol. 160, 1387.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300029-1	A-375_10 mg	10 mg	$202		Add to Cart
BHB21300029-2	A-375_25 mg	25 mg	$451		Add to Cart
BHB21300029-3	A-375_5 mg	5 mg	$117		Add to Cart
BHB21300029-4	A-375_50 mg	50 mg	$808		Add to Cart

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