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Home / Biochemicals / Small Molecules

AMG 9810

SKU : BHB21300004

A Blocker of TRPV1 Channels

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Mfr.No.	A-180, A-180_10 mg, A-180_25 mg, A-180_5 mg, A-180_50 mg
Description	AMG 9810 (#A-180) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H23NO3.
Background	AMG 9810 (E)-3-(4-t-butylphenyl)-N-(2, 3- dihydrobenzo (b) (1,4) dioxin-6-yl) acrylamide is a potent, non-vanilloid, competitive antagonist of the vanilloid receptor 1 (TRPV1) with IC50 values for human TRPV1 of 24.5 nM and rat TRPV1 of 85.6 nM.Additionally, it has been shown to compete with other modes of TRPV1 activation, including protons (IC50s = 92.7 and 294 nM for human and rat, respectively), heat (IC50s = 15.8 and 21 nM for human and rat, respectively), and the endogenous ligands anandamide, N-arachidonoyl dopamine (IC50s = 8.5 and 260 nM for human and rat, respectively), and oleoyldopamine.Furthermore, AMG 9810 blocks capsaicin-induced calcitonin gene-related peptide (CGRP) release and capsaicin-evoked depolarization in rat dorsal root ganglia neurons.Finally, AMG 9810 was shown to be a potent and selective antagonist of TRPV1 that can significantly reverse thermal and mechanical hyperalgesia in an animal model of inflammatory pain1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5 nM - 50 uM.
Reconstitution	Ethanol 50 mM. Centrifuge all product preparations before use (10 000 x g for 1 min).
Cas Number	545395-94-6
Molecular Weight	337.4
Solubility	Ethanol 50 mM. Centrifuge all product preparations before use (10 000 x g for 1 min).
Target	TRPV1 channels
Source	Synthetic
Activity	AMG 9810 blocks TRPV1 with IC50 ~0.01 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-(4-(1,1-dimethylethyl)phenyl)-2-propenamide.

Purity	>96% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Gavva, N.R. et al. (2005) J. Pharmacol. Exp. Ther. 313, 474. Vriens, J. et al. (2009) Mol. Pharmacol. 75, 1262.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300004-1	A-180_10 mg	10 mg	$91		Add to Cart
BHB21300004-2	A-180_25 mg	25 mg	$204		Add to Cart
BHB21300004-3	A-180_5 mg	5 mg	$75		Add to Cart
BHB21300004-4	A-180_50 mg	50 mg	$375		Add to Cart

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