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Home / Biochemicals / Small Molecules

Anisomycin

SKU : BHB21300047

Protein Synthesis Inhibitor

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Alomone Labs

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Mfr.No.	A-520, A-520_10 mg, A-520_100 mg, A-520_25 mg, A-520_5 mg, A-520_50 mg
Description	Anisomycin (#A-520) is a highly pure, natural, and biologically active compound.
Molecular Formula	C14H19NO4.
Synonyms	Natural
Background	Anisomycin is a bacterial antibiotic isolated from Streptomyces griseolus, which inhibits protein synthesis by binding to 60S ribosomal subunits and blocking peptide bond formation, thereby preventing elongation and causing polysome stabilization. This action of Anisomycin monitored the cells for chromosomal DNA degradation and apoptosis.1-5Anisomycin has been widely used as an extremely potent activator of kinase cascades in mammalian cells, especially the stress-activated protein kinase (SAPK2/p38MAPK), kinase subtypes and p46/54JNK.6-13Synergizes with growth factors and phorbol esters, anisomycin superinduce c-fos and c-jun by a number mechanisms, one of which is its ability to act as a potent signalling agonist, producing strong, prolonged activation of the same nuclear responses as epidermal growth factor or tetradecanoyl phorbol acetate.14Anisomycin stimulated serine phosphorylation of IRS-1 and IRS-2, reduced their ability to interact with the insulin receptor and by that blocked the insulin-induced tyrosine phosphorylation of IRS proteins.15
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	22862-76-6
Molecular Weight	265.3
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	Anisomycin is an antibiotic which inhibits protein synthesis1. It also activates stress-activated protein kinases (SAPK) independent of its ability to block translation.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R,3S,4S)-2-((4-Methoxyphenyl)methyl)-3,4-pyrrolidinediol 3-acetate.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Sobin, B. A. et al. (1954) J. Am. Chem. Soc. 76, 4053. Jim?nez, A. et al. (1979) p. 1-19. In F. E. Hahn (ed.), Antibiotics, vol. 5 part 2. Springer-Verlag, New York, N.Y. Barbacid, M. et al. (1975) J. Mol. Biol. 93, 449. Kochi, S.K. et al. (1993) Exp. Cell. Res. 208, 296. Condorelli, G. et al. (2002) J. Biol. Chem. 277, 11013. Cano, E. et al. (1994) Mol. Cell. Biol. 14, 7352. Cano, E. et al. (1995) J. Cell Sci. 108, 3599. Chen, D. et al. (1996) J. Biol. Chem. 271, 6328. Ishikawa, Y. and Kitmura, M. (1999) Biochem. Biophys. Res. Commun. 264, 696. Bogoyevitch, M.A. et al. (1995) J. Biol. Chem. 270, 29710. Sanchez, et al. (1994) Nature 372, 794. Derijard, B. et al. (1994) Cell 76, 1025. Hibi, M. et al. (1993) Genes Dev. 7, 2135. Barros, L.F. et al. (1998) Molecular and Cellular Biology 18, 1844. Hemi, R. et al. (2002) J. Biol. Chem. 277, 8961. Sobin, B.A. et al. (1954) J. Am. Chem. Soc. 76, 4053.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300047-1	A-520_10 mg	10 mg	$42		Add to Cart
BHB21300047-2	A-520_100 mg	100 mg	$213		Add to Cart
BHB21300047-3	A-520_25 mg	25 mg	$85		Add to Cart
BHB21300047-4	A-520_5 mg	5 mg	$31		Add to Cart
BHB21300047-5	A-520_50 mg	50 mg	$117		Add to Cart

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