JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Ascomycin

SKU : BHB21300050

Immunosuppressant

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	A-800, A-800_0.5 mg, A-800_1 mg
Description	Ascomycin (#A-800) is a highly pure, natural, and biologically active compound.
Molecular Formula	C43H69NO12.
Synonyms	Natural
Background	Ascomycin (FK520) is a structurally complex macrolide with immunosuppressant activity. It is an ethyl analog of the known immune suppressant FK506 (Tacrolimus).1,2 Ascomycin acts by binding to a class of cytosolic proteins, the immunophilins, especially macrophilin-12 (FKBP-12). The immunophilin-FK520 complex inhibits calcineurin, a type 2B phosphatase (PP2B).3Ascomycin suppresses the production of Th1 and Th2 cytokines in T lymphocytes, and preferentially inhibits the activation of mast cells (principal cells of the allergic response).4 In human basophils, it potently inhibited anti-IgE-induced histamine and cytokine release, and reduced IgE-dependent p38 MAPK activation.5 It seems that Ascomycin inhibits basophil degranulation at the initial phase of allergic skin reactions.6,7 Ascomycin derivatives are currently developed for the clinical treatment of dermatological diseases.8,9
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 nM.
Reconstitution	DMSO, methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	11011-38-4
Molecular Weight	792
Solubility	DMSO, methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	Ascomycin is an immunosuppressant antifungal antibiotic1,2. It also inhibits calcineurin (PP-2B) activity3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)- 17-ethyl-1,14-dihydroxy-12-((1E)-1-((1S,3S,4S)-4-hydroxy-3-methoxycyclohexyl)prop-1-en-2-yl)-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo(22.3.1.0^{4,9})octacos-18-ene- 2,3,10,16-tetrone.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Arai, T. et al. (1962) J. Antibiot. (Tokyo) 15, 231. Morisaki, M. and Arai, T. (1992) J. Antibiot. (Tokyo) 45, 126. Meadows, R.P. et al. (1993) Biochemistry 32, 754. Kawai, M. et al. (1998) Bioorg. Med. Chem. Lett. 8, 935. Plath, K.E. et al. (2003) Clin. Exp. Allergy 33, 342. Paul, C. et al. (2000) Expert Opin. Investig. Drugs 9, 69. Griffiths, C.E. (2001) Br. J. Dermatol. 144, 679. Wellington, K. and Jarvis, B. (2002) Drugs 62, 817. Quatresooz, P. et al. (2003) Rev. Med. Liege 58, 168. Arai, T. et al. (1962) J. Antibiot. (Tokyo) 15, 231. Morisaki, M. and Arai, T. (1992) J. Antibiot. (Tokyo) 45, 126. Meadows, R.P. et al. (1993) Biochemistry 32, 754.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300050-1	A-800_0.5 mg	0.5 mg	$129		Add to Cart
BHB21300050-2	A-800_1 mg	1 mg	$188		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.