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Home / Biochemicals / Small Molecules

AZ 10606120 dihydrochloride

SKU : BHB21300034

A Potent and Selective Antagonist of P2X7 Receptors

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Mfr.No.	A-405, A-405_10 mg, A-405_25 mg, A-405_5 mg, A-405_50 mg
Description	AZ 10606120 dihydrochloride (#A-405) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C25H36Cl2N4O2 (C25H34N4O2 · 2HCl).
Synonyms	Synthetic
Background	AZ 10606120 dihydrochloride is a potent and selective noncompetitive antagonist of the P2X7 receptor with IC50 value of ~10 nM2. The compound shows little or no effect at other P2X receptor subtypes1,2. In studies conducted in animal models, AZ 10606120 treatment shows antidepressant effects and reduces tumor growth2.P2X receptors are a family of ligand-gated cation channels activated by the binding of extracellular ATP. Seven members of this family have been identified and function in homomeric or heteromeric combinations. P2X7 receptor is a therapeutic target due to its potential involvement in pain and inflammatory disorders1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	607378-18-7
Molecular Weight	495.49
Solubility	Soluble up to 100 mM in DMSO and up to 20 mM in water. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 channels
Activity	AZ 10606120 dihydrochloride is a potent and selective non-competitive antagonist of P2X7 receptors, acting as a negative allosteric modulator shown to inhibit human P2X7 receptors with pIC50 of 8.1-8.91-3. It also inhibits growth and neoangiogenesis of P2X7-expressing tumors in mice4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(1-adamantyl)-N-(2-(2-(2-hydroxyethylamino)ethylamino)quinolin-5-yl)acetamide;dihydrochloride.

Purity	>97%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Michel, A.D. et al. (2008) Br. J. Pharmacol. 153, 737. Allsopp, R.C. et al. (2017) Sci. Rep. 7, 725. Michel, A.D. et al. (2008) Br. J. Pharmacol. 153, 737. Bhattacharya, A. et al. (2013) Br. J. Pharmacol. 170, 624. Allsopp, R.C. et al. (2017) Sci. Rep. 7, 725. Adinolfi, E. et al. (2012) Cancer Res. 72, 2957.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300034-1	A-405_10 mg	10 mg	$168		Add to Cart
BHB21300034-2	A-405_25 mg	25 mg	$373		Add to Cart
BHB21300034-3	A-405_5 mg	5 mg	$117		Add to Cart
BHB21300034-4	A-405_50 mg	50 mg	$672		Add to Cart

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