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Home / Biochemicals / Small Molecules

AZ11645373

SKU : BHB21300033

A Potent and Selective Antagonist of Human P2X7 Receptors

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Alomone Labs

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Mfr.No.	A-395, A-395_10 mg, A-395_25 mg, A-395_5 mg, A-395_50 mg
Description	AZ11645373 (#A-395) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C24H21N3O5S.
Synonyms	Synthetic
Background	AZ11645373 is a potent and highly selective antagonist of the human P2X7 receptor. It demonstrates IC50 values ranging from 5 to 90 nm depending on the cellular assay1. AZ11645373 is inactive on other P2X receptor subtypes and significantly less active on rat receptors1.The P2X7 receptor is a member of ligand-gated ion channels activated by extracellular ATP. This family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are highly expressed throughout autonomic, sensory and central neurons and in visceral smooth muscle, immune cells and epithelia1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-5 uM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	227088-94-0
Molecular Weight	463.51
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	AZ11645373 is a potent and selective antagonist of human P2X7 purinergic receptors (KB = 5-20 nM), significantly less active on rat receptors, and inactive on other P2X receptor subtypes1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-(1-(4-(3-nitrophenyl)phenoxy)-4-pyridin-4-ylbutan-2-yl)-1,3-thiazolidine-2,4-dione.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Stokes, L. et al. (2006) Br. J. Pharmacol. 149, 880. Donnelly-Roberts, D.L. et al. (2009) Br. J. Pharmacol. 157, 1203. Stokes, L. et al. (2006) Br. J. Pharmacol. 149, 880.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300033-1	A-395_10 mg	10 mg	$202		Add to Cart
BHB21300033-2	A-395_25 mg	25 mg	$451		Add to Cart
BHB21300033-3	A-395_5 mg	5 mg	$117		Add to Cart
BHB21300033-4	A-395_50 mg	50 mg	$808		Add to Cart

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