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Home / Biochemicals / Small Molecules

AZD-1332

SKU : BHB21300045

A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors

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Alomone Labs

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Mfr.No.	A-495, A-495_10 mg, A-495_25 mg, A-495_5 mg, A-495_50 mg
Description	AZD-1332 (#A-495) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H19ClFN7O.
Pubchem Cid	49831044
Synonyms	Synthetic
Background	AZD-1332 is a potent and selective inhibitor of the Tropomyosin-related kinase (TrkA, TrkB, and TrkC) receptors. The compound is at least 30-fold more specific towards Trk in cell-based assays over a wide range of other kinases tested. AZD-1332 inhibits Trk kinase activity in cells at low nanomolar concentrations, the compound demonstrates IC50 values of
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Molecular Weight	391.8
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	TrkA, TrkB, TrkC receptors
Activity	AZD-1332 is a potent, selective, and orally bioavailable inhibitor of tyrosine kinase receptors (IC50 values of
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-chloro-2-N-(1-(5-fluoropyridin-2-yl)ethyl)-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Thress, K. et al. (2009) Mol. Cancer. Ther. 8, 1818. Wang, T. et al. (2008) J. Med. Chem. 51, 4672. Thress, K. et al. (2009) Mol. Cancer. Ther. 8, 1818.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300045-1	A-495_10 mg	10 mg	$306		Add to Cart
BHB21300045-2	A-495_25 mg	25 mg	$603		Add to Cart
BHB21300045-3	A-495_5 mg	5 mg	$235		Add to Cart
BHB21300045-4	A-495_50 mg	50 mg	$969		Add to Cart

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