BIX-01294

Mfr.No.	SIH-347
Alternative Names	2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride
Appearance	Cream solid
Function	HMT inhibitor
Inchi	InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
Inchikey	OSXFATOLZGZLSK-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C28H38N6O2*3HCl
Pubchem Cid	25150857
Research Area	Cell Signaling ; Epigenetics and Nuclear Signaling ; Cancer
Safety Phrases	Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
Smiles	CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC.Cl.Cl.Cl
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	935693-62-2
Molecular Weight	600.02
Scientific Background	G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
Solubility	May be dissolved in DMSO (100 mM) or Water (100 mM)
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.025
Purity	>98%
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900135-1	SIH-347-5MG	5 mg	$99		Add to Cart
BHB11900135-2	SIH-347-25MG	25 mg	$322		Add to Cart

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