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Home / Biochemicals / Small Molecules

BQ788 sodium salt

SKU : BHB21300061

A Selective Antagonist of Endothelin B Receptors

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Alomone Labs

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Mfr.No.	B-176, B-176_0.5 mg, B-176_1 mg, B-176_10 mg, B-176_5 mg
Description	BQ788 sodium salt (#B-176) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C34H50N5NaO7.
Background	BQ788 is a synthetic modified tripeptide that acts as a potent, selective and competitive antagonist of the ET-B (endothelin B) receptor, a receptor that belongs to the G-protein coupled receptor (GPCR) superfamily. BQ788 is a soluble compound that does not bind plasma proteins and is metabolized in a short period of time. It lacks oral bioavailability and requires intra-arterial administration. The compound is used in vitro and in vivo to demonstrate the role of endogenous and exogenous endothelin receptor subtypes in physiological and pathophysiological conditions1,2. It displays IC50 values of 1.2 nM in radiolabeled Girardi heart cells and 1300 nM in human neuroblastoma cell line, respectively1.ET-A and ET-B receptors are widely distributed in vascular tissues where they mediate vasoconstriction and in nonvascular tissues such as the liver, kidney, and brain. ET-A receptors have high affinity for ET-1 and ET-2 peptides and relatively low affinity for ET-3, while ET-B receptors show high affinity for all ET isopeptides1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
Cas Number	156161-89-6
Molecular Weight	663.79
Solubility	Soluble in DMSO and ethanol. Centrifuge all products before use (10000 x g 5 min).
Target	ET-B receptor
Source	Synthetic
Activity	BQ788 is a potent and highly specific ET-B receptor antagonist, exhibiting selectivity for ET-B over ET-A human receptors when inhibiting the binding of (125I)-Endothelin-1 (IC50 of 1.2 nM and 1300 nM, respectively)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: sodium;(2R)-2-(((2R)-2-(((2S)-2-(((2S,6R)-2,6-dimethylpiperidine-1-carbonyl)amino)-4,4-dimethylpentanoyl)amino)-3-(1-methoxycarbonylindol-3-yl)propanoyl)amino)hexanoate.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Okada, M. and Nishikibe, M. (2002) Cardiovasc. Drug Rev. 20, 53. Maguire, J.J. and Davenport, A.P. (2015) Semin. Nephrol. 35, 125. Okada, M. and Nishikibe, M. (2002) Cardiovasc. Drug Rev. 20, 53.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300061-1	B-176_0.5 mg	0.5 mg	$134		Add to Cart
BHB21300061-2	B-176_1 mg	1 mg	$184		Add to Cart
BHB21300061-3	B-176_10 mg	10 mg	$680		Add to Cart
BHB21300061-4	B-176_5 mg	5 mg	$509		Add to Cart

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