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Home / Biochemicals / Small Molecules

Capsiate

SKU : BHB21300086

A TRPA1 and TRPV1 Channel Activator

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Alomone Labs

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Mfr.No.	C-255, C-255_10 mg, C-255_25 mg, C-255_5 mg
Description	Capsiate (#C-255) is a highly pure, natural, and biologically active compound.
Molecular Formula	C18H26O4.
Background	Transient receptor potential vanilloid channels (TRPV) are members of the TRP channel superfamily. They are involved in many sensory processes such as pain, temperature and hearing1. Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA12.Capsiate is a natural agonist of TRPA1 and TRPV1 channels with an effective concentration of 1-100 uM and an EC50 of 3 uM when binding to TRPA1. Capsiate is produced by a non-pungent cultivar of red pepper called Capsicum annuum L and is hypothesized to enhance energy metabolism by activating the sympathetic system and suppressing inflammation3.Capsiate has also been found to suppress body fat accumulation in mice through the upregulation of uncoupling proteins. Uncoupling proteins play an important role in body weight maintenance, thermoregulation and energy expenditure4. The magnitude of the long-term weight loss effectiveness of capsaicin in humans has not been clearly demonstrated and further research is required in its relation to combating obesity5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Cas Number	205687-01-0
Molecular Weight	306.4
Solubility	Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	TRPA1, TRPV1 channels
Source	Natural
Activity	Capsiate activates TRPV1 and TRPA1 channels with EC50 = 3 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (4-hydroxy-3-methoxyphenyl)methyl (E)-8-methylnon-6-enoate.

Purity	>94% (HPLC)
Form	Oily material.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Niemeyer, B.A. (2005) Naunyn-Schmiedebergs Arch. Pharmacol. 371, 285. Cvetkov, T.L. et al. (2011) J. Biol. Chem. 286, 38168. Shintaku, K. et al. (2011) Br. J. Pharmacol. 165, 1476. Masuda, Y. et al. (1985) J. Appl. Physiol. 95, 2408. Ludy, M. et al. (2011) Chem. Senses 37, 103. Shintaku, K. et al. (2011) Br. J. Pharmacol. 165, 1476.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300086-1	C-255_10 mg	10 mg	$323		Add to Cart
BHB21300086-2	C-255_25 mg	25 mg	$723		Add to Cart
BHB21300086-3	C-255_5 mg	5 mg	$202		Add to Cart

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