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Home / Biochemicals / Small Molecules

CFMTI

SKU : BHB21300100

A Potent and Selective Antagonist of mGluR1 Receptors

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Mfr.No.	C-365, C-365_10 mg, C-365_25 mg, C-365_5 mg, C-365_50 mg
Description	CFMTI (#C-365) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H16FN5O.
Background	CFMTI is a negative allosteric modulator of mGluR1 receptors with IC50 values of 2.6 and 2.3 nM for human and rat mGluR1 expressed in CHO cells, respectively. CFMTI demonstrates high potency and selectivity for the receptor both in vitro and in vivo after oral administration and shows very low potency for other mGluR subtypes1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly expressed on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells and neural stem cells and the formation of the hippocampus3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 10 uM.
Reconstitution	Up to 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	864864-17-5
Molecular Weight	349.4
Solubility	Up to 10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR1
Source	Synthetic
Activity	CFMTI is a selective and potent allosteric antagonist of mGluR1 receptors. It inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a with IC50 values of 2.6 and 2.3 nM, respectively. It is highly selective for mGluR1 over mGluR5 (2000-fold), and does not affect mGluR subtypes and other receptors at 10 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-cyclopropyl-5-(1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl)-3H-isoindol-1-one.

Purity	>96%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: -20°C.

Product Manual	SDS

Reference	Suzuki, G. et al. (2007) J. Pharmacol. Exp. Ther. 321, 1144. Satow, A. et al. (2008) J. Pharmacol. Exp. Ther. 326, 577. Eom, H.S. et al. (2016) PLoS One 11, e0147538. Satow, A. et al. (2008) J. Pharmacol. Exp. Ther. 326, 577.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300100-1	C-365_10 mg	10 mg	$235		Add to Cart
BHB21300100-2	C-365_25 mg	25 mg	$468		Add to Cart
BHB21300100-3	C-365_5 mg	5 mg	$168		Add to Cart
BHB21300100-4	C-365_50 mg	50 mg	$843		Add to Cart

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