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Home / Biochemicals / Small Molecules

CNQX

SKU : BHB21300076

AMPA/Kainate Receptor Antagonist

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Alomone Labs

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Mfr.No.	C-140, C-140_10 mg, C-140_100 mg, C-140_25 mg, C-140_5 mg, C-140_50 mg
Description	CNQX (#C-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C9H4N4O4.
Background	The first widely used competitive AMPA receptor antagonists were quinoxalinediones (CNQX, DNQX, NBQX), which were highly selective over NMDA receptors but antagonized kainate receptors. CNQX is a potent, competitive AMPA/kainate receptor antagonist. It also acts as an antagonist at the NMDA receptor glycine site.This non-NMDA receptor antagonist inhibits (3H)AMPA binding to quisqualate receptors at submicromolar concentrations. CNQX also selectively blocks the excitatory action of quisqualate and kainate on spinal neurons with little or no effect on that of NMDA.The concentrations that inhibit 50% of (3H)AMPA binding (IC50) for CNQX in dorsal horn neurons is 300 nM1.The association of AMPA receptors with TARP auxiliary subunits converts CNQX from an antagonist to a weak partial agonist. CNQX induces partial domain closure, consistent with the activity of a partial agonist. CNQX blocks both fast AMPA-mediated and slow kainate receptor-mediated mEPSCs2.EC50 values for depression of the monosynaptic ventral root reflex is 1.0 ± 0.3 uM3.Direct binding studies using CNQX as a radioligand show that CNQX binds with high affinity (40 nM) to both high (14 nM) and low (235 nM) affinity AMPA binding sites in rat brain4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	300 nM - 500 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
Cas Number	115066-14-3
Molecular Weight	232.2
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g for 5 min).
Target	AMPA/Kainate receptors
Source	Synthetic
Activity	AMPA/kainate receptor antagonist. The concentrations that inhibit 50% of AMPA binding (IC50) for CNQX in dorsal horn neurons and motoneurons are 300 nM-1.3 uM. It was about one-fifth as effective at kainate binding sites1,2. The association of AMPA receptors with TARPs converts CNQX from an antagonist to a weak partial agonist. CNQX binds with high affinity to both high and low affinity AMPA binding sites in rat brain. CNQX is a potent antagonist in electrophysiological responses mediated by non-NMDA receptors. Effects at NMDA receptors are much weaker.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Honore, T. et al. (1988) Science 241, 701. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Long, S.K. et al. (1990) Br. J. Pharmacol. 100, 850. Watkins, J.C. et al. (1990) Trends Pharmacol. Sci. 11, 25. Honore, T. et al. (1988) Science 241, 701. Long, S.K. et al. (1990) Br. J. Pharmacol. 100, 850.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300076-1	C-140_10 mg	10 mg	$66		Add to Cart
BHB21300076-2	C-140_100 mg	100 mg	$306		Add to Cart
BHB21300076-3	C-140_25 mg	25 mg	$129		Add to Cart
BHB21300076-4	C-140_5 mg	5 mg	$50		Add to Cart
BHB21300076-5	C-140_50 mg	50 mg	$202		Add to Cart

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