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Home / Biochemicals / Small Molecules

Curcumin

SKU : BHB21300083

An Activator of TRPA1 Channels

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Alomone Labs

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Mfr.No.	C-230, C-230_10 g, C-230_25 g, C-230_5 g
Description	Curcumin (#C-230) is a highly pure, natural, and biologically active compound.
Molecular Formula	C21H20O6.
Synonyms	Natural
Background	Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA11.Curcumin is a natural agonist of TRPA1 channels produced from the root Curcuma longa L. with an effective concentration of 10-200 uM and an EC50 of 10 uM. Curcumin is hypothesized to be effective in the prevention and alleviation of various pathologies. Curcumin significantly lowers oxidized proteins, GFAP marker levels and beta-amyloid plaques in a mouse model of Alzheimer's disease2. In rats, curcumin reduces liver damage caused by gastric ethanol infusion. This is mainly done by decreasing hepatic MDA, inhibiting NF-kappaB activation and reducing apoptosis of hepatic cells thus improving hepatic histopathology and reducing the morbidity associated with alcoholic liver disease3. Also, MDX mice treated with curcumin show improvement of grip strength in a dose-dependent manner and a reduction of the CK marker which indicates skeletal muscle injury4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-200 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	458-37-7
Molecular Weight	368.4
Solubility	Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	TRPA1 channels
Activity	Curcumin activates TRPA1 channels with an EC50 of 10 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione.

Purity	>96%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Cvetkov, T.L. et al. (2011) J. Biol. Chem. 286, 38168. Lim, G.P. et al. (2001) J. Neurosci. 21, 8670. Samuhasaneeto, S. et al. (2009) J. Biomed Biotech. 2009, 8. Pan, Y. et al. (2007) Mol. Cells 25, 531. Leamy, A.W. et al. (2011) Neurosci. Lett. 503, 157.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300083-1	C-230_10 g	10 g	$41		Add to Cart
BHB21300083-2	C-230_25 g	25 g	$85		Add to Cart
BHB21300083-3	C-230_5 g	5 g	$31		Add to Cart

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