CZC 54252 Hydrochloride

Mfr.No.	SIH-439
Alternative Names	N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide hydrochloride
Appearance	Yellow solid
Function	LRRK2 inhibitor
Inchi	InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
Inchikey	KWCBHUPLQMUKAF-UHFFFAOYSA-N
Mode Of Action	Inhibitor
Molecular Formula	C22H26Cl2N6O4S
Research Area	Cell Signaling
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	1191911-27-9
Molecular Weight	541.5
Scientific Background	CZC 54252 Hydrochloride is a potent leucine-rich repeat kinase 2 (LRRK2) inhibitor.
Solubility	Soluble to 100 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Reference	1. Kramer T., Lo Monte F., Göring S., Okala Amombo G.M., & Schmidt B. (2012) ACS Chem. Neuro. 3(3): 151–160.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900223-1	SIH-439-5MG	5 mg	$118		Add to Cart
BHB11900223-2	SIH-439-25MG	25 mg	$471		Add to Cart