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Home / Biochemicals / Small Molecules

D-AP5

SKU : BHB21300117

A Competitive NMDA Receptor Antagonist

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Mfr.No.	D-145, D-145_1 mg, D-145_10 mg, D-145_100 mg, D-145_25 mg, D-145_250 mg, D-145_5 mg, D-145_50 mg, D-145_500 mg
Description	D-AP5 (#D-145) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C5H12NO5P.
Synonyms	Synthetic
Background	D-2-Amino-5-phosphopentanoic acid (D-AP5) is an NMDA receptor antagonist that competitively inhibits the glutamate binding site of NMDA receptors with an IC50 value of 30 uM2. D-AP5 has been shown to cause damage in memory and learning processes and has the ability to trigger synaptic potentiation in the mature hippocampus2.Blockade by NMDA antagonists may cause glutamate-elicited calcium influx. In addition, it is known for its antinociceptive action.The NMDA receptor plays important physiological and pathological roles in the central nervous system. The receptor binds the neurotransmitter L-glutamate and meditates the majority of the fast excitatory neurotransmission in the mammalian brain. In addition, it induces current formation in neurons. Evidence shows that the inhibitory effects of AP5 are independent of membrane potential but decrease with increasing stimulation frequency1,2.Several studies have suggested that local blockade of NMDA receptors attenuates chronic tinnitus, thus D-AP5 could have a clinical role in tinnitus protection3. Administration of D-AP5 reverses axotomy effects such as contractile properties and locomotor behavior in animals without any observable side-effects. D-AP5 may present therapeutic potential in other models of excitotoxic injuries4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	79055-68-8
Molecular Weight	197.1
Solubility	25 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors
Activity	D-AP5 is an NMDA receptor antagonist. IC50 = 0.28 uM (NR2A), 0.46 uM (NR2B), 1.6 uM (NR2C)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: (2R)-2-amino-5-phosphonopentanoic acid.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Ambert, N. et al. (2010) Open Access Bioinformatics 2, 113. Nosyreva, E. et al. (2014) Front Mol. Neurosci. 7, 94. Brozoski, T.J. et al. (2013) PLoS One 8, e77674. Petsanis, K. et al. (2012) BMC Physiol. 12, 5. Feuerbach, D. et al. (2010) Eur. J. Pharmacol. 637, 46.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300117-1	D-145_1 mg	1 mg	$53		Add to Cart
BHB21300117-2	D-145_10 mg	10 mg	$111		Add to Cart
BHB21300117-3	D-145_100 mg	100 mg	$702		Add to Cart
BHB21300117-4	D-145_25 mg	25 mg	$256		Add to Cart
BHB21300117-5	D-145_250 mg	250 mg	$1398		Add to Cart
BHB21300117-6	D-145_5 mg	5 mg	$81		Add to Cart
BHB21300117-7	D-145_50 mg	50 mg	$432		Add to Cart
BHB21300117-8	D-145_500 mg	500 mg	$2210		Add to Cart

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