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Home / Biochemicals / Small Molecules

DL-AP3

SKU : BHB21300127

An Antagonist of mGluR1 Receptors

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Mfr.No.	D-275, D-275_100 mg, D-275_250 mg, D-275_50 mg, D-275_500 mg
Description	DL-AP3 (#D-275) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C3H8NO5P.
Synonyms	Synthetic
Background	DL-AP3 is a racemic compound of 2-amino-3-phosphonopropionic acid that acts as a potent and competitive antagonist of mGluR1 receptors. It demonstrates an IC50 value of 1 mM for rat mGluR1 when challenged with glutamate2. DL-AP3 has neuroprotective effects in the gerbil model of global ischemia1,2.Glutamate is the most abundant excitatory neurotransmitter in the central nervous system. It modulates the activity of many types of synapses by activating, in part, metabotropic glutamate receptors (mGluRs), members of the G-protein coupled receptor (GPCR) superfamily. These receptors are divided into three groups based on sequence homology with a total of eight subtypes, mGluR1 to mGluR8. Type 1 mGluRs are mainly detected on post-synaptic neurons and affect the fate of neuronal progenitor cells and neural stem cells, and are important for the formation of the hippocampus3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 mM.
Reconstitution	Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	5652-28-8
Molecular Weight	169.07
Solubility	Soluble in water, 1eq NaOH and aqueous buffers.Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR1
Activity	DL-AP3 is a selective competitive antagonist of group I metabotropic glutamate receptors, at 1 mM suppressing mGluR1 response in an agonist dependent manner1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-amino-3-phosphonopropanoic acid.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage of solutions: -20°C.

Product Manual	SDS

Reference	Schoepp, D.D. et al. (1999) Neuropharmacology 38, 1431. Hawkinson, J.E. et al. (1996) Eur. J. Pharmacol. 307, 219. Eom, H.S. et al. (2016) PLoS One 11, e0147538. Schoepp, D.D. et al. (1999) Neuropharmacology 38, 1431.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300127-1	D-275_100 mg	100 mg	$66		Add to Cart
BHB21300127-2	D-275_250 mg	250 mg	$129		Add to Cart
BHB21300127-3	D-275_50 mg	50 mg	$50		Add to Cart
BHB21300127-4	D-275_500 mg	500 mg	$219		Add to Cart

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