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Home / Biochemicals / Small Molecules

DQP-1105

SKU : BHB21300124

A Potent Noncompetitive Antagonist of GluN2D/C-Containing NMDA Receptors

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Alomone Labs

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Mfr.No.	D-210, D-210_10 mg, D-210_25 mg, D-210_5 mg, D-210_50 mg
Description	DQP-1105 (#D-210) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C29H24BrN3O4.
Background	DQP-1105 is a potent and noncompetitive antagonist of GluN2D and GluN2C-containing N-methyl-d-aspartate (NMDA) receptors displaying IC50 values of 2.7 uM and 8.5 uM towards NR2D and NR2C-containing receptors, respectively1. DQP-1105 exhibits significant selectivity towards these receptors over NR2B and NR2A-containing receptors. DQP-105 inhibits the pregating step without changing the stability of the open pore conformation.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction and stroke. NMDA receptors mediate physiological functions such as learning and memory formation, glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-20 uM.
Reconstitution	Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	380560-89-4
Molecular Weight	558.43
Solubility	Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	GluN2D and GluN2C-containing NMDA receptors
Source	Synthetic
Activity	DQP-1105 is a potent, noncompetitive NMDA receptor antagonist, exhibiting significant selectivity for NR2D and NR2C-containing receptors (IC50 = 2.7 uM and 8.5 uM, respectively) over NR2B and NR2A-containing receptors (IC50 = 121 uM and 206 uM, respectively)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-((3Z)-5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenylquinolin-3-ylidene)pyrazolidin-1-yl)-4-oxobutanoic acid.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Acker, T.M. et al. (2011) Mol. Pharmacol. 80, 782. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45. Acker, T.M. et al. (2011) Mol. Pharmacol. 80, 782.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300124-1	D-210_10 mg	10 mg	$168		Add to Cart
BHB21300124-2	D-210_25 mg	25 mg	$373		Add to Cart
BHB21300124-3	D-210_5 mg	5 mg	$117		Add to Cart
BHB21300124-4	D-210_50 mg	50 mg	$672		Add to Cart

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