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Home / Biochemicals / Small Molecules

E-4031

SKU : BHB21300134

A Blocker of KV11.1 (hERG) K+ Channels

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Mfr.No.	E-500, E-500_0.5 mg, E-500_1 mg, E-500_10 mg, E-500_25 mg, E-500_5 mg, E-500_50 mg
Description	E-4031 (#E-500) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H27N3O3S2HCl2H2O.
Background	E-4031 is a methanesulfonanilide class III antiarrhythmic agent known to inhibit KV11.1 (hERG) channels. Sub-micromolar concentration of E-4031, selectively blocks Kv11.1 channels, either in heterologous systems,1,2 cardiac cells3 and cardiac preparations.4 E-4031 was shown to rescue the functional expression of mutated (LQ2) KV11.1 channels in HEK cells.5 E-4031 (40 uM) treatment also prevented FAK phosphorylation and Rac1 activity (only in HEK cells expressing the KV11.1 subunit).6 In rat carotid chemoreceptor cells, 1 uM E-4031 inhibited the KV current, to a larger extent in postnatal cells, establishing the developmental disappearance of KV11.1 channels and their contribution to the response to hypoxia.7 E-4031 (1 uM) accelerated myoblast fusion, probably by blocking KV11.1 channels that leads to depolarization.8
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	113559-13-0
Molecular Weight	510.5
Solubility	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KV11.1 K+ channels
Source	Synthetic
Activity	E-4031 is a methsnesulfonanilide class III antiarrhythmic agent. It specifically blocks hERG (KV11.1) voltage-gated K+ channel current in heterologous systems1,2, cardiac cells3 and cardiac preparations4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: (1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonyl-aminobenzoyl)piperidine).

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to one week at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Spector, P.S. et al. (1996) Circ Res. 78, 499. Zhou, Z. et al. (1998) Biophys. J. 74, 230. Sanguinetti, M.C. and Jurkiewicz, N.K. (1990) J. Gen Physiol. 96, 195. Wettwer, E. et al. (1991) J. Cardiovasc. Pharmacol. 17, 480. Anderson, C.L. et al. (2006) Circulation 113, 365. Cherubini, A. et al. (2005) Mol. Biol. Cell 16, 2972. Kim, I. et al. (2005) J. Appl. Physiol. 98, 1469. Liu, J.H. et al. (2003) Development 130, 3437. Spector, P.S. et al. (1996) Circ. Res. 78, 499. Zhou, Z. et al. (1998) Biophys. J. 74, 230. Sanguinetti, M.C. and Jurkiewicz, N.K. (1990) J. Gen. Physiol. 96, 195. Wettwer, E. et al. (1991) J. Cardiovasc. Pharmacol. 17, 480.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300134-1	E-500_0.5 mg	0.5 mg	$81		Add to Cart
BHB21300134-2	E-500_1 mg	1 mg	$103		Add to Cart
BHB21300134-3	E-500_10 mg	10 mg	$251		Add to Cart
BHB21300134-4	E-500_25 mg	25 mg	$421		Add to Cart
BHB21300134-5	E-500_5 mg	5 mg	$188		Add to Cart
BHB21300134-6	E-500_50 mg	50 mg	$738		Add to Cart

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