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Home / Biochemicals / Small Molecules

Eliprodil

SKU : BHB21300130

An Antagonist of NMDA Receptors and N- and P-Type CaV Channels

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Mfr.No.	E-155, E-155_10 mg, E-155_25 mg, E-155_5 mg, E-155_50 mg
Description	Eliprodil (#E-155) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C20H23ClFNO.
Synonyms	Synthetic
Background	Eliprodil, also known as SL 82-0715, is a non-competitive NMDA (N-methyl-D-aspartate) receptor antagonist with neuroprotective properties. Eliprodil blocks the receptor through interaction with a modulatory polyamine site. The drug has also been shown to inhibit neuronal N- and P-type Ca2+ channel currents1.NMDARs play an important role in a variety of cellular processes and brain functions including synaptic plasticity, addiction and stroke. They also mediate physiological functions such as learning and memory formation. They play a role in glutamate excitotoxicity and are involved in many neurodegenerative conditions including Alzheimer's disease2.Studies show that eliprodil has the ability to protect against ischaemia-induced neurodegeneration when the drug is administered post-occlusion and demonstrates antidepressant-like actions in preclinical tests predictive of clinical efficacy1,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	119431-25-3
Molecular Weight	347.9
Solubility	>25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors, N-, P-type CaV channels
Activity	Eliprodil is a non-competitive NR2B-selective NMDA glutamate receptor antagonist 1, N and P-type voltage-dependent Ca2+ channels blocker 2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(4-chlorophenyl)-2-(4-((4-fluorophenyl)methyl)piperidin-1-yl)ethanol.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Bath, C.P. et al. (1996). Eur. J. Pharmacol. 299, 103. Black, S.A. et al. (2014) Front. Cell. Dev. Biol. 2, 45. Layer, R.T. et al. (1995) Pharmacol. Biochem. Behav. 52, 621. Avenet, P. et al. (1997) Neurosci. Lett. 223, 133. Bath, C.P. et al. (1996). Eur. J. Pharmacol. 299, 103.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300130-1	E-155_10 mg	10 mg	$85		Add to Cart
BHB21300130-2	E-155_25 mg	25 mg	$184		Add to Cart
BHB21300130-3	E-155_5 mg	5 mg	$66		Add to Cart
BHB21300130-4	E-155_50 mg	50 mg	$333		Add to Cart

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