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Home / Biochemicals / Small Molecules

FK-506

SKU : BHB21300145

Calcineurin (PP-2B) Inhibitor-Immunosuppressant

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Mfr.No.	F-900, F-900_1 mg
Description	FK-506 (#F-900) is a highly pure, natural, and biologically active compound.
Molecular Formula	C44H69NO12.
Synonyms	Natural
Background	FK 506 (Tacrolimus), a macrolide compound isolated from Streptomyces tsukubaensis, is a potent immunosuppressive compound that inhibits T-cell activation and is an inhibitor of fungal growth (10 to 100 times more potent than Cyclosporin A).1-3 FK-506 binds and inhibits, in vitro, the activity of immunophilin proteins known as FK 506-binding protein (FKBP), in a variety of organisms, ranging from yeast to humans.4-8Immunosuppression activity of FK-506 seems to be due to FK-506/FKBP complex that inhibits the heterodimeric Ca2+/calmodulin-dependent phosphatase Calcineurin. This, in turn, prevents the Calcineurin-dependent activation of interleukin-2 transcription and T-cell proliferation.9-12 FK-506 inhibits FKBP activities, increases sarcoplasmic reticulum Ca2+ release and decreases the ability of Na+/Ca2+ exchange to extrude Ca2+ from the cell.13
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 pM - 50 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	104987-11-3
Molecular Weight	804.03
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	FK-506 is an immunosuppressant and inhibits calcineurin (PP-2B)1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11, 12,13,14,15,16,17,18,19,24,25,26,26a Hexadecahydro-5,19 - dihydroxy-3-((1E)-2-((1R,3R,4R)-4-hydroxy-3-methoxycyc lohexyl)-1- methylethenyl)-14,16-dimethoxy-4,10,12,18-te tramethyl-8-(2-propen-1-yl)- 15,19-epoxy-3H-pyrido(2,1-c )(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Kino, T. et al. (1987) J Antibiot. 40, 1249. Kino, T. et al. (1987) J Antibiot. 40, 1256. Goto, T. et al. (1991) Transplant Proc. 23, 2713. Rosen, M.K. and Schreiber, S.L. (1992) Angew. Chem. Int. Ed. Engl. 31, 384. Schreiber, S.L. et al. (1992) Immunol Today. 13, 136. Harding, M.W. et al. (1989) Nature. 341, 758. Bierer, B. et al. (1990) Science. 250, 556. Jin, Y. et al. (1991) PNAS 88, 6677. Liu, J. et al. (1991) Cell 66, 807. O'Keefe, S.J. et al. (1992) Nature (London) 357, 692. Dumont, F.J. et al. (1992) Journal of Experimental Medicine 176, 751. McCall, E. et al. (1996) Circ. Res. 79, 1110. Fruman, D.A. et al. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 3686. Cardenas, M.E. et al. (1998) Trends Biotechnol. 16, 427. Kino, T. et al. (1987) J. Antibiot. 40, 1249.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300145-1	F-900_1 mg	1 mg	$280		Add to Cart
BHB21300145-2	F-900_1 mg	5x1 mg	$1106		Add to Cart

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