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Home / Biochemicals / Small Molecules

FTX-3.3

SKU : BHB21300135

A Blocker of P-Type CaV Channels

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Mfr.No.	F-120, F-120_1 mg
Description	FTX-3.3 (#F-120) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C12H31N7.
Pubchem Cid	9970537
Synonyms	Synthetic
Background	FTX is a polyamine component of the venom of the American funnel web spider Agelenopsis aperta, and has been described as a selective antagonist of P-type voltage-dependent Ca2+ channels1-2. However, it has been demonstrated that FTX has actions at other sites including NMDA and GABA receptors and also on T-type calcium channels3.FTX-3.3 (reputed to be structurally identical to the native FTX) has been synthesized4-5 and shown to block P-type calcium channels in rat cerebellar Purkinje cells6. It antagonizes P-, N-, and L-type calcium channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies; Its IC50 against P-, N-, and L-type channels are ~0.13 mM, ~0.24 mM and ~0.24 mM, respectively7.FTX-3.3 does not reduce whole-cell sodium current recorded from SK.N.SH cells and is therefore ion selective8.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-1 mM.
Reconstitution	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Molecular Weight	273.4
Solubility	Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Target	P-type Ca2+ channels
Activity	FTX-3.3 is a synthetic polyamine1-2, reputed to be structurally identical to the native Funnel Web Spider Toxin (FTX). It blocks P-, N-, and L-type Ca2+ channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1, 4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Llinas, R. et al. (1989) Proc. Natl. Acad. Sci. U.S.A. 85, 1689. Scott, R.H. et al. (1992) Br. J. Pharmacol. 106, 199. Blagbrough, I.S. et al. (1994) Tetra. Lett. 35, 2057. Moya, E. et al. (1994) Tetra. Lett. 35, 2061. Dupere, J.R.B. et al. (1996) Neuropharmacology 35, 1. Norris, T.M. et al. (1996) Mol. Pharmacol. 50, 939. Fatehi, M. et al. (1997) Neuropharmacology 36, 185. Blagbrough, I.S. et al. (1994) Tetra. Lett. 35, 2057. Moya, E. et al. (1994) Tetra. Lett. 35, 2061. Norris, T.M. et al. (1996) Mol. Pharmacol. 50, 939.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300135-1	F-120_1 mg	1 mg	$261		Add to Cart
BHB21300135-2	F-120_1 mg	5x1 mg	$1030		Add to Cart

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