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Home / Biochemicals / Small Molecules

Gabazine hydrobromide

SKU : BHB21300159

An Antagonist of GABA(A) and Glycine Receptors

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Mfr.No.	G-216, G-216_10 mg, G-216_25 mg, G-216_5 mg, G-216_50 mg
Description	Gabazine hydrobromide (#G-216) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H17N3O3HBr.
Synonyms	Synthetic
Background	Gabazine (SR-95531) is a specific, competitive and potent antagonist of GABA(A) receptors. The compound also blocks glycine receptors but with lower affinity. SR-95531 acts as an allosteric inhibitor of GABA(A) receptor channel opening1,2 and blocks GABA-evoked currents with an IC50 of 0.44 uM1. When SR 95531 was administered intravenously it was shown to cause seizures in mice3.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate the GABA action, a major inhibitory neurotransmitter, throughout the central nervous system (CNS) and play an important role in inhibiting cell excitation in the CNS. The GABA(A) receptor is considered to be a major target of anti-seizure drugs4,5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-1 uM.
Reconstitution	Soluble in water, DMSO and methanol. Centrifuge all product preparations before use (10000 x g, 5 min).
Cas Number	104104-50-9
Molecular Weight	368.23
Solubility	Soluble in water, DMSO and methanol. Centrifuge all product preparations before use (10000 x g, 5 min).
Target	GABA(A), Glycine receptors
Activity	Gabazine is a competitive antagonist of the GABA(A) receptor, selectively inhibiting GABA-evoked currents (IC50 = 0.44 uM), but not currents evoked by pentobarbiton and etomidate1. It is also a low-affinity glycine receptor antagonist (KB = 191 uM)2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(6-imino-3-(4-methoxyphenyl)pyridazin-1-yl)butanoic acid;hydrobromide.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Uchida, I. et al. (1996) Eur. J. Pharmacol. 307, 89. Beato, M. et al. (2007) J. Physiol. 580, 171. Heaulme, M. et al. (1986) Brain Res. 384, 224. Pomara, N. et al. (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry. 56, 35. Iqbal, F. et al. (2011) Bioorg. Med. Chem. Lett. 21, 4252. Uchida, I. et al. (1996) Eur. J. Pharmacol. 307, 89. Beato, M. et al. (2007) J. Physiol. 580, 171.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300159-1	G-216_10 mg	10 mg	$92		Add to Cart
BHB21300159-2	G-216_25 mg	25 mg	$210		Add to Cart
BHB21300159-3	G-216_5 mg	5 mg	$76		Add to Cart
BHB21300159-4	G-216_50 mg	50 mg	$375		Add to Cart

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