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Home / Biochemicals / Small Molecules

Gambogic acid

SKU : BHB21300164

Kir2.1 Channel Blocker, Apoptosis Inducer, Caspase Activator and Bcl-2 Inhibitor

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Alomone Labs

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Mfr.No.	G-250, G-250_10 mg, G-250_100 mg, G-250_25 mg, G-250_5 mg, G-250_50 mg
Description	Gambogic acid (#G-250) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C38H44O8.
Synonyms	Synthetic
Background	Gambogic acid is a compound originally derived from the gamboges resin of the tree, Garcinia hanburyi. Gambogic acid has been shown to pose cytotoxic activity against tumor cells in culture through a mechanism involving apoptosis1.Gambogic acid was found to act as a slow blocker of Kir2.1 with relatively potent IC50 values of 100 nM and lower2.Gambogic acid is better known for its agonistic action on caspases, proteases involved in apoptosis and as a Bcl-2 inhibitor. Bcl-2-family proteins are regulators of apoptosis1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-1 uM.
Reconstitution	Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	2752-65-0
Molecular Weight	628.75
Solubility	Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	Caspases, Bcl-2, Bax, CD71, Kir2.1
Activity	Gambogic acid is a cell-permeable apoptosis inducer in multiple cancer cell lines, acting via activation of caspases (EC50 of 0.78-1.64 uM), competitive inhibition of Bcl-2 family proteins (IC50 of 0.66-2.02), altering the expression of Bcl-2 and Bax genes, and binding CD71 transferrin receptors to prevent their internalization (IC50 = 4.1 uM). Gambogic acid is also a slow blocker of Kir2.1 channels (IC50 <= 100 nM)1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2Z)-2-Methyl-4-((1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthen-1-yl)-2-butenoic acid.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C up to four months. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Zhai, D. et al. (2008) Mol. Cancer Ther. 7, 1639. Zaks-Makhina, E. et al. (2009) J. Biol. Chem. 284, 15432. Shi, X. et al. (2013) Clin. Cancer Res. 20, 151.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300164-1	G-250_10 mg	10 mg	$85		Add to Cart
BHB21300164-2	G-250_100 mg	100 mg	$459		Add to Cart
BHB21300164-3	G-250_25 mg	25 mg	$168		Add to Cart
BHB21300164-4	G-250_5 mg	5 mg	$66		Add to Cart
BHB21300164-5	G-250_50 mg	50 mg	$287		Add to Cart

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