JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

gamma-Aminobutyric acid

SKU : BHB21300146

A Ligand of GABA(A), GABA(B) Receptors and GABA Transporters

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	G-110, G-110_100 g, G-110_25 g
Description	gamma-Aminobutyric acid (#G-110) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C4H9NO2.
Synonyms	Synthetic
Background	gamma-aminobutyric acid (GABA) is an amino acid derivate, synthesized from glutamate by the pyridoxal-L-phosphate (PLP)-dependent enzyme, glutamate decarboxylase (GAD)1. GABA provides the primary inhibitory signaling in the adult mammalian brain (CNS), and, to some degree of controversy, exerts a depolarizing response in the developing brain2.GABA is an agonist of two main receptor classes in the CNS: GABAA, an ionic ligand gated channel, and GABAB, a metabotrophic, G-protein coupled receptor. GABAA is assembled by 5 out of 16 possible subunits with alpha, beta and either a gamma or a delta (2:2:1 stoichiometry) being the most common. With an EC50 between 3 - 12uM it interacts with GABA to allow either an influx or an efflux of Cl- ions, into and out of the cell, respectively3. GABAB is a heterodimer comprised of the subunits GABAB1 and GABAB2. It reduces neurotransmitter release by inhibiting Ca2+ channels when activated presynaptically, and facilitates inward rectifying potassium channels, postsynaptically1.GABA deficiency is often the prime cause for epilepsy, with other notably disorders being autism4, spasticity, anxiety disorders, schizophrenia, and stiff-person syndrome5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 uM
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	56-12-2
Molecular Weight	103.1
Solubility	Water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	GABA(A), GABA(B) receptors, GABA transporters
Activity	1-100 uM activated recombinant alpha1beta1gamma2 channels with EC50 = 5 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-Aminobutanoic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Briggs, S.W. et al. (2011) Neural Plasticity 2011, 16. Khakhalin, A.S. et al. (2011) J. Neurophysiol. 106, 1065. Esmaeili, A. et al. (2008) J. N. Physiol. 101, 349. Salehi, B. et al. (2012) Int. J. Neuropsycopharm. FirstView, 1. Wong, C.G. et al. (2008) Ann. Neurol. 54 Suppl 6, S3. Horne, A.L. et al. (1992) Br. J. Pharmacol. 107, 732.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300146-1	G-110_100 g	100 g	$55		Add to Cart
BHB21300146-2	G-110_25 g	25 g	$27		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.