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Home / Biochemicals / Small Molecules

Garcinolic acid

SKU : BHB21300153

A Positive Modulator of P2X7 Receptors

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Mfr.No.	G-155, G-155_0.1 mg, G-155_0.5 mg, G-155_1 mg, G-155_2 mg
Description	Garcinolic acid (#G-155) is a highly pure, natural, and biologically active compound.
Molecular Formula	C38H46O9.
Pubchem Cid	6857794
Synonyms	Natural
Background	Garcinolic acid, a type of xanthone, is a positive modulator of the purinergic P2X7 receptors. It facilitates and potentiates cellular responses mediated by the purinergic P2X7 receptors at concentrations over 10 uM1,2.P2X receptors are ligand-gated cation-permeable channel complexes that are activated by extracellular ATP. This family contains seven subtypes: P2X1-P2X7 that can be assembled as trimeric complexes. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are expressed in almost all tissues, particularly in cells of haematopoietic origin1,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 uM.
Reconstitution	Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).
Molecular Weight	646.78
Solubility	Soluble in DMSO, DMF and other organic solvents. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	Garcinolic acid is a natural compound isolated from Garcinia resin, shown to facilitate and potentiate cellular responses mediated by the purinergic P2X7 receptors at over 10 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (4R)-4-((2E)-3-carboxy-3-methylprop-2-en-1-yl)-14-hydroxy-6,6,18-trimethyl-21-(3-methylbut-2-en-1-yl)-18-(4-methylpent-3-en-1-yl)-12-oxo-2,5,19-trioxapentacyclo(11.8.0.0^{3,7}.0^{3,11}.0^{15,20})henicosa-1(21),10,13,15(20),16-pentaene-4-carboxylic acid

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Fischer, W. et al. (2014) Purinergic Signal. 10, 313. Deng, Y.X. et al. (2012) Fitoterapia 83, 1548. Stokes, L. et al. (2006) Br. J. Pharmacol. 149, 880. Fischer, W. et al. (2014) Purinergic Signal. 10, 313.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300153-1	G-155_0.1 mg	0.1 mg	$168		Add to Cart
BHB21300153-2	G-155_0.5 mg	0.5 mg	$406		Add to Cart
BHB21300153-3	G-155_1 mg	1 mg	$649		Add to Cart
BHB21300153-4	G-155_2 mg	2 mg	$1036		Add to Cart

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