JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

GV-58

SKU : BHB21300151

An Activator of CaV2.2 and CaV2.1 Ca2+ Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	G-140, G-140_10 mg, G-140_25 mg, G-140_5 mg, G-140_50 mg
Description	GV-58 (#G-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H26N6OS.
Background	GV-58, a Ca2+ channel agonist, is selective for N- (CaV2.2) and P/Q-type (CaV2.1) channels. GV-58 was developed as a modification of (R)-roscovitine, which was previously shown to be a Ca2+ channel agonist. 100 uM GV-58 was originally tested on N-, P/Q-, or L-type channels expressed in tsA-201 cells. GV-58 was shown to be more potent on N- and P/Q Ca2+ channels with an EC50 = 6.8 and 9.9 uM, respectively over L-type calcium channels (EC50 > 100 uM)1. GV-58 slows the closing of the channel, resulting in a large increase in total Ca2+ entry during motor nerve action potential activity.GV-58 is being tested for the treatment of neuromuscular weakness2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	1402821-41-3
Molecular Weight	374.2
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	CaV2.1, CaV2.2 Ca2+ channels
Source	Synthetic
Activity	GV-58 is an opener of N- and P/Q-type Ca2+ channels1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R)-2-((6-{((5-Methylthiophen-2-yl)methyl)amino}-9-propyl-9H-purin-2-yl)amino)butan-1-ol.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Tarr, T.B. et al. (2012) Ann. N. Y. Acad. Sci. 1275, 85. Liang, M. et al. (2012) ACS Med. Chem. Lett. 3, 985. Tarr, T.B. et al. (2013) J. Neurosci. 33, 10559.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300151-1	G-140_10 mg	10 mg	$210		Add to Cart
BHB21300151-2	G-140_25 mg	25 mg	$460		Add to Cart
BHB21300151-3	G-140_5 mg	5 mg	$132		Add to Cart
BHB21300151-4	G-140_50 mg	50 mg	$824		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.