JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

GW-2580

SKU : BHB21300165

An Inhibitor of Trk Receptors and cFMS/CSF-1 Receptor Kinases

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	G-255, G-255_10 mg, G-255_100 mg, G-255_25 mg, G-255_5 mg, G-255_50 mg
Description	GW-2580 (#G-255) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C20H22N4O3.
Synonyms	Synthetic
Background	GW-2580 is a small-molecule pyrimidine derivative, that acts as a potent and selective inhibitor of Colony-stimulating factor 1 (CSF-1) signaling through cFMS kinase receptor. GW-2580 completely inhibits human cFMS kinase in vitro at 0.06 uM1. The compound also acts as an inhibitor of Trk Receptors and shows binding towards TrkB, TrkC, and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 uM3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	870483-87-7
Molecular Weight	366.41
Solubility	Soluble up to 100mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	CSF-1R receptor, Trk receptor
Activity	GW-2580 is a potent and selective inhibitor of cFMS/CSF-1 receptor kinase, shown to completely and selectively inhibit human cFMS kinase activity at 60 nM, and fully suppress CSF-1 induced cell growth at 1 uM, in vitro. Orally bioavailable and active in vivo1. GW 2580 also binds to TrkB, TrkC and TrkA with Kd values of 36 nM, 120 nM and 630 nM, respectively,2 and fully inhibits BDNF-induced TrkB phosphorylation in cells at 3 uM3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-((3-methoxy-4-((4-methoxyphenyl)methoxy)phenyl)methyl)pyrimidine-2,4-diamine.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C.

Product Manual	SDS

Reference	Conway, J.G. et al. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 16078. Karaman, M.W. et al. (2008) Nat. Biotechnol. 26, 127. Cohen, M.S. et al. (2011) Proc. Natl. Acad. Sci. U. S. A. 108, 11246. Conway, J.G. et al. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 16078. Karaman, M.W. et al. (2008) Nat. Biotechnol. 26, 127. Cohen, M.S. et al. (2011) Proc. Natl. Acad. Sci. U. S. A. 108, 11246.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300165-1	G-255_10 mg	10 mg	$66		Add to Cart
BHB21300165-2	G-255_100 mg	100 mg	$406		Add to Cart
BHB21300165-3	G-255_25 mg	25 mg	$145		Add to Cart
BHB21300165-4	G-255_5 mg	5 mg	$50		Add to Cart
BHB21300165-5	G-255_50 mg	50 mg	$254		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.