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Home / Biochemicals / Small Molecules

HMA

SKU : BHB21300170

An Antagonist of Na+/H+ Exchangers, P2X7 receptors and TRPA1, ASIC3 Channels

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Alomone Labs

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Mfr.No.	H-130, H-130_100 mg, H-130_25 mg, H-130_50 mg
Description	HMA (#H-130) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C12H18ClN7O.
Synonyms	Synthetic
Background	HMA is a TRPA1 channel blocker with an IC50 value of 35 uM, an inhibitor of the Na+/H+ exchangers (NHE) and a blocker of ASIC3 channel (acid-sensing ion channels)1-3. HMA also antagonizes P2X7 receptors, although it is not potent4.HMA as an NHE inhibitor, is considered to be a promising adjuvant drug for overcoming acquired resistance to treatment in various malignant hemopathies1-3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-300 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	1428-95-1
Molecular Weight	311.77
Solubility	Up to 100mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	NHE exchangers, TRPA1, ASIC3 channels, P2X7 receptors
Activity	HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal with IC50 of 35 uM1. It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 uM for various NHE isoforms2. HMA also blocks ASIC3 channels by 51% at 20 uM3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Banke, T.G. (2011) Brain Res. 1381, 21. Kuduk, S.D. et al. (2009) Bioorg. Med. Chem. Lett. 19, 2514. Chessell, I.P. et al. (1998) Br. J. Pharmacol. 124, 1314. Banke, T.G. (2011) Brain Res. 1381, 21. Masereel, B. et al. (2003) Eur. J. Med. Chem. 38, 547. Kuduk, S.D. et al. (2009) Bioorg. Med. Chem. Lett. 19, 2514.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300170-1	H-130_100 mg	100 mg	$202		Add to Cart
BHB21300170-2	H-130_25 mg	25 mg	$66		Add to Cart
BHB21300170-3	H-130_50 mg	50 mg	$117		Add to Cart

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