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Home / Biochemicals / Small Molecules

ICA 121431

SKU : BHB21300176

A Potent and Selective Blocker of NaV1.3 and NaV1.1 Channels

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Mfr.No.	I-170, I-170_10 mg, I-170_25 mg, I-170_5 mg, I-170_50 mg
Description	ICA 121431 (#I-170) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C23H19N3O3S2.
Background	ICA 121431 is a synthetic potent and selective inhibitor of human NaV1.3 and NaV1.1 channels. ICA 121431 has an effective concentration of 10nM - 1uM with an IC50 of 13 and 23 nM on the NaV1.3 and NaV1.1 channels respectively. Unlike other known NaV inhibitors ICA inhibits the Nav channel by interacting with the S1-S4 voltage sensor segment of homologous domain 4. The sensitivity and selectivity of different NaV subtype receptors to ICA is influenced by the extracellular amino acid residues in the facing regions of the S2 and S3 transmembrane segments. Currently, most NaV modulators are unable to distinguish between NaV channel subtypes therefore limiting their usage due to systemic toxicity. ICA's interaction with the region of the channel that controls voltage sensitivity enables subtype selective modulation and may be used as an efficient tool for innovative drug development1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
Cas Number	313254-51-2
Molecular Weight	449.5
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NaV1.1, NaV1.3 channels
Source	Synthetic
Activity	ICA 121431 blocks NaV channels with IC50 values of 13 and 23 nM for NaV1.3 and NaV1.1 respectively1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl) acetamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	McCormack, K. et al. (2013) Proc. Natl. Acad. Sci. U. S. A. 110, E2724. McCormack, K. et al. (2013) Proc. Natl. Acad. Sci. U. S. A. 110, E2724.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300176-1	I-170_10 mg	10 mg	$117		Add to Cart
BHB21300176-2	I-170_25 mg	25 mg	$262		Add to Cart
BHB21300176-3	I-170_5 mg	5 mg	$66		Add to Cart
BHB21300176-4	I-170_50 mg	50 mg	$476		Add to Cart

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