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Home / Biochemicals / Small Molecules

Icilin

SKU : BHB21300174

A Potent Activator of TRPM8 Channels

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Mfr.No.	I-145, I-145_10 mg, I-145_100 mg, I-145_25 mg, I-145_5 mg, I-145_50 mg
Description	Icilin (#I-145) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H13N3O4.
Synonyms	Synthetic
Background	Icilin is a synthetic cooling substance that acts as a potent TRPM8 channel activator with an EC50 value of 0.2 ± 0.1uM1. This compound also shown to activate TRPA1 ion channel but at higher concentrations. Activation of TRPM8 channel by icilin produces Na+ and Ca2+ ion influx that results in cellular depolarization and the feeling of cold. Icilin has the ability to produce behavioral activation in rats and mice1-3.TRPM8 is a Ca2+-permeable channel, a member of the 'long' or melastatin (M) group of TRP channels and is activated by temperatures in the range of 8-28°C or by cooling compounds such as icilin. The TRPM8 gene is expressed and up-regulated in prostate cancer and other malignancies. TRPM8 channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons1,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	36945-98-9
Molecular Weight	311.29
Solubility	Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	TRPM8 channel
Activity	Icilin is a potent TRPM8 channel activator (EC50 = 0.2 uM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737. Kayano, T. et al. (2010) J. Vet. Med. Sci. 72, 1531. Kim, J. et al. (2011) Brain Res. 1384, 110. Tsumura, M. et al. (2013) PLoS One 8, e82233. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300174-1	I-145_10 mg	10 mg	$66		Add to Cart
BHB21300174-2	I-145_100 mg	100 mg	$425		Add to Cart
BHB21300174-3	I-145_25 mg	25 mg	$117		Add to Cart
BHB21300174-4	I-145_5 mg	5 mg	$50		Add to Cart
BHB21300174-5	I-145_50 mg	50 mg	$235		Add to Cart

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