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Home / Biochemicals / Small Molecules

IDRA 21

SKU : BHB21300173

A Positive Allosteric Modulator of AMPA Receptors

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Mfr.No.	I-140, I-140_10 mg, I-140_25 mg, I-140_5 mg, I-140_50 mg
Description	IDRA 21 (#I-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C8H9ClN2O2S.
Background	IDRA 21 is a well characterized benzothiadiazine positive allosteric modulator of glutamate AMPA receptors. IDRA 21 produced a concentration-dependent inhibition of glutamate-induced inactivation of membrane currents in recombinant HEK 293 (human embryonic kidney) cells stably transfected with human GluR1/2 flip receptors. IDRA 21 doubled the charge transfer at a concentration of 70 uM, suggesting that this compound can facilitate excitatory neurotransmission via GluR 1/2 receptors. The drug originally considered in the nootropic class of agents (which have had limited success as cognitive-enhancing agents clinically) has been shown to inhibit the rate of desensitization of the AMPA receptor during prolonged exposure to competitive agonists. Thus, the drug acts to strengthen glutamatergic synapses and requires the release of endogenous glutamate for its pharmacological actions. This property of IDRA 21 supports its ability to enhance long-term potentiation (LTP), particularly within the hippocampus1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-500 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	22503-72-6
Molecular Weight	232.7
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	AMPA receptors
Source	Synthetic
Activity	IDRA 21 is a selective AMPA receptor agonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Buccafusco, J.J. et al. (2004) Neuropharmacology 46, 10. Arai, A. et al. (1996) Neuroreport 7, 2211.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300173-1	I-140_10 mg	10 mg	$117		Add to Cart
BHB21300173-2	I-140_25 mg	25 mg	$254		Add to Cart
BHB21300173-3	I-140_5 mg	5 mg	$66		Add to Cart
BHB21300173-4	I-140_50 mg	50 mg	$459		Add to Cart

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